This project aims to better understand the selective vulnerability of neuronal populations in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). You will study this using human post-mortem tissue of donors with ALS and FTD. Specifically, you will investigate the biochemical properties of two specialized neuronal populations, the von Economo neurons and the Betz cells. You will use techniques such as immunohistochemistry, in situ hybridization, laser capture microscopy, proteomics and RNA sequencing. This project is part of the Selective vulnerability research line headed by Dr. Anke Dijkstra. The research line is embedded in the Molecular Neuroscience Group at the Swammerdam Institute for Life Sciences (SILS, Faculty of Science). You will be supervised by Dr. Anke Dijkstra and Dr. Lars van der Heide.
This project aims to better understand the selective vulnerability of neuronal populations in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). You will study this using human post-mortem tissue of donors with ALS and FTD. Specifically, you will investigate the biochemical properties of two specialized neuronal populations, the von Economo neurons and the Betz cells. You will use techniques such as immunohistochemistry, in situ hybridization, laser capture microscopy, proteomics and RNA sequencing. This project is part of the Selective vulnerability research line headed by Dr. Anke Dijkstra. The research line is embedded in the Molecular Neuroscience Group at the Swammerdam Institute for Life Sciences (SILS, Faculty of Science). You will be supervised by Dr. Anke Dijkstra and Dr. Lars van der Heide.
As a PhD student you will develop into an independent researcher. Your tasks and activities will include:
You are/have:
We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students. Based on a full-time appointment (38 hours per week) the gross monthly salary will range from €2.901 in the first year to €3.707 (scale P) in the last year. This does not include 8% holiday allowance and 8,3% year-end allowance. The UFO profile PhD candidate is applicable.
Besides the salary and a vibrant and challenging environment at Science Park we offer you multiple fringe benefits:
As a PhD student you will develop into an independent researcher. Your tasks and activities will include:
You are/have:
We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students. Based on a full-time appointment (38 hours per week) the gross monthly salary will range from €2.901 in the first year to €3.707 (scale P) in the last year. This does not include 8% holiday allowance and 8,3% year-end allowance. The UFO profile PhD candidate is applicable.
Besides the salary and a vibrant and challenging environment at Science Park we offer you multiple fringe benefits:
The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain. The Swammerdam Institute for Life Sciences (SILS) is an institute of the Faculty of Science. This institute contains 16 research groups (with approximately 240 employees) that work on one of the four themes: Microbiology, Cell & Systems Biology, Green Life Sciences and Neuroscience.
The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain. The Swammerdam Institute for Life Sciences (SILS) is an institute of the Faculty of Science. This institute contains 16 research groups (with approximately 240 employees) that work on one of the four themes: Microbiology, Cell & Systems Biology, Green Life Sciences and Neuroscience.
Do you recognize yourself in the job profile? Then we look forward to receiving your application by 23 February 2025. Applications in .pdf should include:
We will invite potential candidates for interviews in the first half of March 2025. Please mention the months (not just years) in your CV when referring to your education and work experience. A knowledge security check can be part of the selection procedure (for details: national knowledge security guidelines).
Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact:
Do you recognize yourself in the job profile? Then we look forward to receiving your application by 23 February 2025. Applications in .pdf should include:
We will invite potential candidates for interviews in the first half of March 2025. Please mention the months (not just years) in your CV when referring to your education and work experience. A knowledge security check can be part of the selection procedure (for details: national knowledge security guidelines).
Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact:
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