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Are you interested in why some individuals thrive in complex societies, whereas others don’t seem to find their way? In this project, we aim to better understand the neurobiological factors that influence coping in a demanding environment. You will study the combined effects of early life adversity and adolescent THC exposure on later life social behavior and stress coping in a mouse model.

Are you interested in why some individuals thrive in complex societies, whereas others don’t seem to find their way? In this project, we aim to better understand the neurobiological factors that influence coping in a demanding environment. You will study the combined effects of early life adversity and adolescent THC exposure on later life social behavior and stress coping in a mouse model.
Although cannabis is generally considered a ‘safe’ drug, there are concerns about its increased potency, with a mean THC concentration that has doubled in the last 20 years. This is especially worrisome when a young brain is exposed to cannabis, since the endocannabinoid system in the brain plays an important role in development and neuronal finetuning. Frequent adolescent cannabis use (daily or near-daily) can have lasting impairments in information processing speed and perceptual reasoning, can cause a drop in IQ and result in lower academic achievement in general. Moreover, a link with mental health problems has been observed too. How exactly these associations are causally and neurobiologically related is still a matter of debate. It has been reported that lasting effects of THC exposure during the adolescent period are mostly revealed in close interaction with other factors, like early life environmental conditions, which have been formulated in the multiple hit model for mental health vulnerability.
In this project, we aim to better understand how coping with the environment develops after THC exposure and how adverse environmental factors can be at play. We will study animals in so called complex or enriched environments, and under stressful circumstances and investigate their behavior, next to changes in brain plasticity, including in-vivo and ex-vivo electrophysiology (in collaboration with Dr. Marlies Oostland and Dr. Pascal Chameau). We use the vapour method of THC exposure, which has translational value and face validity.
The project relates to the framework of the Centre for Urban Mental Health (UMH), an interdisciplinary research center at the UvA, where complexity and dynamics of mental health problems in an urban environment is approached from an integrative angle. You will be working in the Brain Plasticity group at the Swammerdam Institute for Life Sciences at the Faculty of Sciences of the University of Amsterdam under the supervision of Dr. Rixt van der Veen and Prof. Paul Lucassen.

Although cannabis is generally considered a ‘safe’ drug, there are concerns about its increased potency, with a mean THC concentration that has doubled in the last 20 years. This is especially worrisome when a young brain is exposed to cannabis, since the endocannabinoid system in the brain plays an important role in development and neuronal finetuning. Frequent adolescent cannabis use (daily or near-daily) can have lasting impairments in information processing speed and perceptual reasoning, can cause a drop in IQ and result in lower academic achievement in general. Moreover, a link with mental health problems has been observed too. How exactly these associations are causally and neurobiologically related is still a matter of debate. It has been reported that lasting effects of THC exposure during the adolescent period are mostly revealed in close interaction with other factors, like early life environmental conditions, which have been formulated in the multiple hit model for mental health vulnerability.
In this project, we aim to better understand how coping with the environment develops after THC exposure and how adverse environmental factors can be at play. We will study animals in so called complex or enriched environments, and under stressful circumstances and investigate their behavior, next to changes in brain plasticity, including in-vivo and ex-vivo electrophysiology (in collaboration with Dr. Marlies Oostland and Dr. Pascal Chameau). We use the vapour method of THC exposure, which has translational value and face validity.
The project relates to the framework of the Centre for Urban Mental Health (UMH), an interdisciplinary research center at the UvA, where complexity and dynamics of mental health problems in an urban environment is approached from an integrative angle. You will be working in the Brain Plasticity group at the Swammerdam Institute for Life Sciences at the Faculty of Sciences of the University of Amsterdam under the supervision of Dr. Rixt van der Veen and Prof. Paul Lucassen.
As a PhD student you will develop into an independent researcher, your tasks and activities will include:
You are/have
We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.
Your salary will range between €3,059 in the first year to €3,881 gross per month in the last year of employment, based on a fulltime employment (38 hours per week). This sum does not include the 8% holiday pay and the 8.3% end-of-year bonus. A favorable tax agreement, the 30% ruling, may apply to non-Dutch applicants. The Collective Labour Agreement for Dutch Universities (CAO NU) is applicable.
Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.
As a PhD student you will develop into an independent researcher, your tasks and activities will include:
You are/have
We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.
Your salary will range between €3,059 in the first year to €3,881 gross per month in the last year of employment, based on a fulltime employment (38 hours per week). This sum does not include the 8% holiday pay and the 8.3% end-of-year bonus. A favorable tax agreement, the 30% ruling, may apply to non-Dutch applicants. The Collective Labour Agreement for Dutch Universities (CAO NU) is applicable.
Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.
The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.
The Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences.
Within the Brain Plasticity group we study structural and functional plasticity of the brain in relation to stress and disease. More info on the Center for Urban Mental Health can be found here; https://www.centreforurbanmentalhealth.com.
The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.
The Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences.
Within the Brain Plasticity group we study structural and functional plasticity of the brain in relation to stress and disease. More info on the Center for Urban Mental Health can be found here; https://www.centreforurbanmentalhealth.com.
If you feel the profile fits you, and you are interested in the position, we look forward to receiving your application. We accept applications until and including 20 May 2026. Only complete applications received within the response period via the link will be considered.
Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact: Dr. Rixt van der Veen ([email protected])
Applications should include the following information (all files besides your CV should be submitted in one single pdf file):
A knowledge security check can be part of the selection procedure.
(for details: national knowledge security guidelines)
We will invite potential candidates for interviews in May-June 2026.
If you feel the profile fits you, and you are interested in the position, we look forward to receiving your application. We accept applications until and including 20 May 2026. Only complete applications received within the response period via the link will be considered.
Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact: Dr. Rixt van der Veen ([email protected])
Applications should include the following information (all files besides your CV should be submitted in one single pdf file):
A knowledge security check can be part of the selection procedure.
(for details: national knowledge security guidelines)
We will invite potential candidates for interviews in May-June 2026.








