PhD position on the effects of early life adversity and adolescent THC exposure on coping behavior

PhD position on the effects of early life adversity and adolescent THC exposure on coping behavior

Working at the UvA

Join us!

Although cannabis is generally considered a ‘safe’ drug, there are concerns about its increased potency, with a mean THC concentration that has doubled in the last 20 years. This is especially worrisome when a young brain is exposed to cannabis, since the endocannabinoid system in the brain plays an important role in development and neuronal finetuning. Frequent adolescent cannabis use (daily or near-daily) can have lasting impairments in information processing speed and perceptual reasoning, can cause a drop in IQ and result in lower academic achievement in general. Moreover, a link with mental health problems has been observed too. How exactly these associations are causally and neurobiologically related is still a matter of debate. It has been reported that lasting effects of THC exposure during the adolescent period are mostly revealed in close interaction with other factors, like early life environmental conditions, which have been formulated in the multiple hit model for mental health vulnerability.

In this project, we aim to better understand how coping with the environment develops after THC exposure and how adverse environmental factors can be at play. We will study animals in so called complex or enriched environments, and under stressful circumstances and investigate their behavior, next to changes in brain plasticity, including in-vivo and ex-vivo electrophysiology (in collaboration with Dr. Marlies Oostland and Dr. Pascal Chameau). We use the vapour method of THC exposure, which has translational value and face validity. 

The project relates to the framework of the Centre for Urban Mental Health (UMH), an interdisciplinary research center at the UvA, where complexity and dynamics of mental health problems in an urban environment is approached from an integrative angle. You will be working in the Brain Plasticity group at the Swammerdam Institute for Life Sciences at the Faculty of Sciences of the University of Amsterdam under the supervision of Dr. Rixt van der Veen and Prof. Paul Lucassen.

Working at the UvA

Join us!

Although cannabis is generally considered a ‘safe’ drug, there are concerns about its increased potency, with a mean THC concentration that has doubled in the last 20 years. This is especially worrisome when a young brain is exposed to cannabis, since the endocannabinoid system in the brain plays an important role in development and neuronal finetuning. Frequent adolescent cannabis use (daily or near-daily) can have lasting impairments in information processing speed and perceptual reasoning, can cause a drop in IQ and result in lower academic achievement in general. Moreover, a link with mental health problems has been observed too. How exactly these associations are causally and neurobiologically related is still a matter of debate. It has been reported that lasting effects of THC exposure during the adolescent period are mostly revealed in close interaction with other factors, like early life environmental conditions, which have been formulated in the multiple hit model for mental health vulnerability.

In this project, we aim to better understand how coping with the environment develops after THC exposure and how adverse environmental factors can be at play. We will study animals in so called complex or enriched environments, and under stressful circumstances and investigate their behavior, next to changes in brain plasticity, including in-vivo and ex-vivo electrophysiology (in collaboration with Dr. Marlies Oostland and Dr. Pascal Chameau). We use the vapour method of THC exposure, which has translational value and face validity. 

The project relates to the framework of the Centre for Urban Mental Health (UMH), an interdisciplinary research center at the UvA, where complexity and dynamics of mental health problems in an urban environment is approached from an integrative angle. You will be working in the Brain Plasticity group at the Swammerdam Institute for Life Sciences at the Faculty of Sciences of the University of Amsterdam under the supervision of Dr. Rixt van der Veen and Prof. Paul Lucassen.

All about this vacancy

What are you going to do?

As a PhD student you will develop into an independent researcher, your tasks and activities will include:

  • completion and defense in public of a doctoral dissertation within four years;
  • participating in the design of the research project;
  • performing electrophysiological and neurobiological laboratory analyses, as well as animal behavioral tasks;
  • analysis, interpretation and presentation of the obtained data;
  • reporting of your results at local and (inter-)national meetings and publish in international, peer-reviewed journals;
  • attending meetings within the SILS groups and UMH gatherings;
  • participating in our PhD training program;
  • assist in teaching activities, supervising Bachelor and Master theses, and tutoring students.

What do we require?

You are/have

  • an enthusiastic, motivated and dedicated scientist with a (research) master’s degree with relevant experience in Life Sciences, e.g. Biomedical Sciences or a related area, preferably with a proven interest in the endocannabinoid system, (social/cognitive) behavior, electrophysiological methods, endocrinological or stress research;
  • experience with practical lab work and have worked with animals before, you are preferably in possession of the Article 9 certificate;
  • excellent analytical and communicative skills and a clear and concise writing style;
  • well-organized, independent, pro-active and perseverant in the face of a setback;
  • last, but not least: a teamplayer, a pleasant colleague in the team and able to work within an interdiciplinary environment. 

Our offer

We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students. 

Your salary will range between €3,059 in the first year to €3,881 gross per month in the last year of employment, based on a fulltime employment (38 hours per week). This sum does not include the 8% holiday pay and the 8.3% end-of-year bonus. A favorable tax agreement, the 30% ruling, may apply to non-Dutch applicants. The Collective Labour Agreement for Dutch Universities (CAO NU) is applicable.

Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.

All about this vacancy

What are you going to do?

As a PhD student you will develop into an independent researcher, your tasks and activities will include:

  • completion and defense in public of a doctoral dissertation within four years;
  • participating in the design of the research project;
  • performing electrophysiological and neurobiological laboratory analyses, as well as animal behavioral tasks;
  • analysis, interpretation and presentation of the obtained data;
  • reporting of your results at local and (inter-)national meetings and publish in international, peer-reviewed journals;
  • attending meetings within the SILS groups and UMH gatherings;
  • participating in our PhD training program;
  • assist in teaching activities, supervising Bachelor and Master theses, and tutoring students.

What do we require?

You are/have

  • an enthusiastic, motivated and dedicated scientist with a (research) master’s degree with relevant experience in Life Sciences, e.g. Biomedical Sciences or a related area, preferably with a proven interest in the endocannabinoid system, (social/cognitive) behavior, electrophysiological methods, endocrinological or stress research;
  • experience with practical lab work and have worked with animals before, you are preferably in possession of the Article 9 certificate;
  • excellent analytical and communicative skills and a clear and concise writing style;
  • well-organized, independent, pro-active and perseverant in the face of a setback;
  • last, but not least: a teamplayer, a pleasant colleague in the team and able to work within an interdiciplinary environment. 

Our offer

We offer a temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students. 

Your salary will range between €3,059 in the first year to €3,881 gross per month in the last year of employment, based on a fulltime employment (38 hours per week). This sum does not include the 8% holiday pay and the 8.3% end-of-year bonus. A favorable tax agreement, the 30% ruling, may apply to non-Dutch applicants. The Collective Labour Agreement for Dutch Universities (CAO NU) is applicable.

Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.

Your place at the UvA

About us

The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.

The Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences.

Within the Brain Plasticity group we study structural and functional plasticity of the brain in relation to stress and disease. More info on the Center for Urban Mental Health can be found here; https://www.centreforurbanmentalhealth.com.

More about the UvA

The University of Amsterdam is ambitious, creative and committed. An inspiration to students since 1632, a vanguard player in international science and a partner in innovation.
The University of Amsterdam is the largest university in the Netherlands, with the broadest range of courses on offer. An intellectual hub with 42,000 students, 6,000 staff and 3,000 PhD students. Connected by a culture of curiosity.

Your place at the UvA

This is where you will be working

About us

The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.

The Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences.

Within the Brain Plasticity group we study structural and functional plasticity of the brain in relation to stress and disease. More info on the Center for Urban Mental Health can be found here; https://www.centreforurbanmentalhealth.com.

More about the UvA

The University of Amsterdam is ambitious, creative and committed. An inspiration to students since 1632, a vanguard player in international science and a partner in innovation.
The University of Amsterdam is the largest university in the Netherlands, with the broadest range of courses on offer. An intellectual hub with 42,000 students, 6,000 staff and 3,000 PhD students. Connected by a culture of curiosity.

Important to know

Your application & contact

If you feel the profile fits you, and you are interested in the position, we look forward to receiving your application. We accept applications until and including 20 May 2026. Only complete applications received within the response period via the link will be considered.

Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact: Dr. Rixt van der Veen ([email protected])

Applications should include the following information (all files besides your CV should be submitted in one single pdf file):

  • a detailed CV including the months (not just years) when referring to your education and work experience;
  • a letter of motivation;
  • two letters of recommendation, including names and email addresses of references who have worked with you before.

A knowledge security check can be part of the selection procedure.

(for details: national knowledge security guidelines)

We will invite potential candidates for interviews in May-June 2026.

Acquisition in response to this vacancy is not appreciated.

Diversity, Equity & Inclusion

As an employer, the UvA maintains an equal opportunities policy. We value diversity and are fully committed to being a place where everyone feels at home. We nurture inquisitive minds and perseverance and allow room for persistent questioning. With us, curiosity and creativity are the prevailing culture.
Studies show that women and members of underrepresented groups only apply for jobs if they meet 100% of the qualifications. Do you meet the educational requirements but not yet all of the requested experience? The UvA encourages you to apply anyway.

Important to know

Your application & contact

If you feel the profile fits you, and you are interested in the position, we look forward to receiving your application. We accept applications until and including 20 May 2026. Only complete applications received within the response period via the link will be considered.

Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact: Dr. Rixt van der Veen ([email protected])

Applications should include the following information (all files besides your CV should be submitted in one single pdf file):

  • a detailed CV including the months (not just years) when referring to your education and work experience;
  • a letter of motivation;
  • two letters of recommendation, including names and email addresses of references who have worked with you before.

A knowledge security check can be part of the selection procedure.

(for details: national knowledge security guidelines)

We will invite potential candidates for interviews in May-June 2026.

Acquisition in response to this vacancy is not appreciated.
As an employer, the UvA maintains an equal opportunities policy. We value diversity and are fully committed to being a place where everyone feels at home. We nurture inquisitive minds and perseverance and allow room for persistent questioning. With us, curiosity and creativity are the prevailing culture.
Studies show that women and members of underrepresented groups only apply for jobs if they meet 100% of the qualifications. Do you meet the educational requirements but not yet all of the requested experience? The UvA encourages you to apply anyway.

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