PhD position in Early Life Stress and Alzheimer's Disease

Your work will focus on assessing the effects of early life stress on mitochondria biology in synapses, glial cells and blood cells of WT and AD mice. In addition, you will test whether manipulations of mitochondria via the diet or targeted strategies protect against AD-related deficits after early life stress in preclinical mouse models. Finally, in a cohort of individuals that has been exposed to undernutrition during pregnancy, a form of early life stress, you will examine if this affects mitochondrial measures in blood monocytes and if this can predict cognitive and brain aging.

Tasks and responsibilities:

• complete and defend a PhD thesis within the official appointment duration of four years;
• gain knowledge of the field through literature survey, discussion with team members, and internal lab meetings;
• contribute to the design of experiments and perform experiments in the lab;
• perform and analyze preclinical mouse in vivo and in vitro experiments;
• take a leading role in writing manuscripts;
• be an active member of the research teams at both SILS and AMC and present your results at (inter)national scientific meetings; 
• participate in the Faculty of Science PhD training programme;
• assist in teaching undergraduates and Master’s students and co-supervise junior scientists (technicians, MSc/BSc students).

You are excited about science and have a particular interest in and preferably have knowledge of early life origins of disease and Alzheimer’s Disease. You like a challenge and are not afraid of combining work on preclinical mouse models with work on human data. You have good statistical skills and experience with statistical packages such as SPSS. You like to work in diverse settings as you have to combine work in the lab with work in an Epidemiology group. You are a team player and a nice colleague who enjoys being part of an interdisciplinary team of scientists. Finally, you have good time management skills enabling you to meet the projects’ deadlines for finishing analyses, reports and other deliverables.    

Your experience and profile  

You have/are

• a MSc degree in Biology, Neuroscience/ (neuro-)immunology or related fields;
• preferably experience with big data and omics analyses and coding (e.g. python, R);
• affinity and experience with performing animal experiments;
• experience with classical neuroscientific methods (e.g. dissections, immunohistochemistry, western blot, PCR, in vitro assays, cell type sorting);
• good analytical, writing and presenting skills;  
• fluent in English, both written and spoken and are willing to learn Dutch (in case not Dutch native speaker).

It will work in your advantage if you have experience with mitochondria research and with performing statistical analyses on large datasets.

A temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students. The preferred starting date is 01 March 2025.

Based on a full-time appointment (38 hours per week) the gross monthly salary will range from €2,872 in the first year to €3,670 (scale P) in the last year. This does not include 8% holiday allowance and 8,3% year-end allowance. The UFO profile PhD candidate is applicable.

Besides the salary and a vibrant and challenging environment at Science Park we offer you multiple fringe benefits:

• 232 holiday hours per year (based on fulltime);
• multiple courses to follow from our Teaching and Learning Centre;
• a complete educational program for PhD students;
• a pension at ABP for which UvA pays two third part of the contribution;
• the possibility to follow courses to learn Dutch;
• help with housing for a studio or small apartment when you’re moving from abroad.