You will investigate how gut- and faecal-derived extracellular vesicles (EVs) and their molecular cargo influence the microbiome in Parkinson’s disease. Using unique bacterial isolates from colonic, ileal, and fecal samples of PD patients and matched controls, you will explore EV-microbiome interactions, focusing on bacterial gene targets, growth, virulence, and abundance. Combining EV profiling, microbial culturomics, in vitro co-cultures, and patient-derived intestinal organoid models, your work will experimentally validate how EVs modulate bacterial function and gut physiology. This project aims to uncover EV-based biomarkers and mechanisms underlying gastrointestinal dysfunction in PD, ultimately offering new insights into the gut-brain axis and potential microbiome-targeted strategies for early diagnosis and intervention.

Experience and profile:

• A recent Ph.D. in a relevant discipline (e.g., microbiology, molecular biology, biochemistry, biotechnology), with demonstrated hands-on experience in EV biology, microbial culturomics, or gut-microbiome studies, and one or more first-author publications in a peer-reviewed journal.
• Hands-on experience in extracellular vesicle isolation, purification, and molecular profiling (e.g., RNA/protein cargo analysis, advanced imaging, analytical chemistry). Experience with in vitro microbial cultures ((an)-aerobic), co-culture systems, and gut-mimicking models is advantageous.
• A motivated and collaborative researcher with an open, proactive mindset, capable of taking ownership of their project while actively engaging with the research group and consortium, contributing to discussions, incorporating feedback, and supporting shared responsibilities.
• Lead manuscript preparation and contribute to scientific (and possibly societal) communication of the project’s results.
• Fluency in English, both written and spoken.

A temporary contract for 38 hours a week, preferably starting before December 2025, for a duration of 24 months, with a probation period of 2 months. The salary, depending on relevant experience before the beginning of the employment contract, will be € 3.546 to €5.538 gross per month, based on a fulltime contract (38 hours a week). This is exclusive 8% holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable.

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